Test Code | Test | Methodology |
120 | Adenovirus, Group Specific Antibody | DIA |
L115 | Burkholderia pseudomallei | ELISA |
107 | Cytomegalovirus African green monkey (SA6) | DIA |
W107 | Cytomegalovirus African green monkey (SA6) | WB |
108 | Cytomegalovirus Chimpanzee (ChCMV) | DIA |
106 | Cytomegalovirus Rhesus (RhCMV) | DIA |
109 | Cytomegalovirus Squirrel monkey(SquiCMV) | DIA |
131 | Encephalomyocarditis Virus (EMCV) | DIA |
110 | Epstein Barr Virus (EBV) | DIA |
1135 | Filovirus-Ebola (Reston) | DIA |
80488 | Filovirus-Ebola (Sudan) | DIA |
80487 | Filovirus-Ebola (Zaire) | DIA |
80491 | Filovirus-Ebola (Zaire/Sudan/Reston) | DIA |
80496 | Filovirus-Ebola (Zaire/Sudan/Reston) & Marburg (Musoke) | DIA |
80492 | Filovirus-Marburg (Musoke) | DIA |
136 | Foamyvirus, Group Specific Antibody | DIA |
200 | Hepatitis A Total Antibody | EIA |
201 | Hepatitis A IgM Antibody | CMIA |
202 | Hepatitis B Surface Antigen Antibody (anti-HBs) | CMIA |
1202 | Hepatitis B Surface Antigen (HBsAg) | CMIA |
2202 | Hepatitis B Core Antibody (anti-HBc) | CMIA |
7024 | Hepatitis B Core IgM Antibody | CMIA |
3202 | Hepatitis C Antibody | CMIA |
100 | Herpes B-Virus | DIA |
L100 | Herpes B-Virus | ELISA |
W100 | Herpes B-Virus Western Blot | WB |
101 | Herpes simplex virus type 1 (HSV-1) | DIA |
102 | Herpes simplex virus type 2 (HSV-2) | DIA |
114 | Herpesvirus papio 2 (HVP2) | DIA |
105 | Herpesvirus Saimiri | DIA |
104 | Herpesvirus Tamarinus | DIA |
140 | Human Varicella Zoster Virus (VZV) | DIA |
123 | Influenza A (Flu A) | DIA |
124 | Influenza B (Flu B) | DIA |
151 | Leptospirosis | ELISA |
132 | Lymphocytic Choriomeningitis Virus (LCMV) | DIA |
112 | Measles | DIA |
L112 | Measles | ELISA |
133 | Monkeypox virus (Copenhagen strain) | DIA |
125 | Parainfluenza 1 (Paraflu 1) | DIA |
126 | Parainfluenza 2 (Paraflu 2) | DIA |
127 | Parainfluenza 3 (Paraflu 3) | DIA |
249 | Poliovirus | DIA |
137 | Rabies | DIA |
128 | Respiratory Syncytial Virus (RSV) | DIA |
139 | Rotavirus (SA11) | DIA |
103 | SA8 (African green monkey herpesvirus) | DIA |
134 | Simian hemorrhagic fever virus (SHFV) | DIA |
L121 | Simian Immunodeficiency virus(SIV) | ELISA |
W121 | Simian Immunodeficiency virus (SIV) | WB |
121 | Simian Immunodeficiency virus (SIV) | DIA |
L1110 | Simian Retrovirus type D (SRV) | ELISA |
W1110 | Simian Retrovirus type D (SRV) | WB |
1110 | Simian Retrovirus type D (SRV) | DIA |
L118 | Simian-T-lymphotropic virus Type 1 (STLV-1) | ELISA |
W118 | Simian-T-lymphotropic virus Type 1 (STLV-1) | WB |
118 | Simian-T-lymphotropic virus Type 1 (STLV-1) | DIA |
L2118 | Simian-T-lymphotropic virus Type 2 (STLV-2) | ELISA |
W2118 | Simian-T-lymphotropic virus Type 2 (STLV-2) | WB |
L111 | Simian Varicella Virus (SVV) | ELISA |
111 | Simian Varicella Virus (SVV) | DIA |
129 | SV5 (Simian Parainfluenza) | DIA |
130 | SV40 (Simian Papovavirus-Macaques) | DIA |
6028 | Toxoplasma IgG | ELISA |
6029 | Toxoplasma IgM | ELISA |
L154 | Trypanosoma cruzi IgG | ELISA |
L155 | Trypanosoma cruzi IgM | ELISA |
Tyrpanosoma cruzi (Chagas disease) IgM-ELISA
L155
0.5-1.0 ml serum
Chagas disease is a parasitic infection caused by T. curzi, which is transmitted by triatomid insect vectors to vertebrate hosts. Natural T.cruzi infection has been reported in many non-human primates, including Macaca sp., a baboon, great apes, squirrel monkeys, owl monkeys, marmosets, tamarins, spider monkeys, woolly monkeys, cebus monkeys and uakaris. T. cruzi is commonly spread between monkeys in the wild by reduviid bugs, but it also can be spread in captive monkey colonies by blood-to blood exposure, saliva, sexual activity and transplacental transmission. The infection of T. cruzi in non-human primates causes nonspecific clinical signs, such as fever, generalized edema without necrosis or hemorrhage, anemia, hepatosplenomegaly, lymphadenitis and myocarditis. The diagnosis of acute infection of T. cruzi can be made by identifying parasites by microscopic examination of fresh blood or by PCR. Serological screening of T. cruzi IgM antibodies can detect infected animals in the very early infection stage.
Trypanosoma cruzi (Chagas disease) IgG-ELISA
L154
0.5-1.0 ml serum
Chagas disease is a parasitic infection caused by T. curzi, which is transmitted by triatomid insect vectors to vertebrate hosts. Natural T.cruzi infection has been reported in many non-human primates, including Macaca sp., a baboon, great apes, squirrel monkeys, owl monkeys, marmosets, tamarins, spider monkeys, woolly monkeys, cebus monkeys and uakaris. T. cruzi is commonly spread between monkeys in the wild by reduviid bugs, but it also can be spread in captive monkey colonies by blood-to blood exposure, saliva, sexual activity and transplacental transmission. The infection of T. cruzi in non-human primates causes nonspecific clinical signs, such as fever, generalized edema without necrosis or hemorrhage, anemia, hepatosplenomegaly, lymphadenitis and myocarditis. The diagnosis of acute infection of T. cruzi can be made by identifying parasites by microscopic examination of fresh blood or by PCR. Serological screening of T. cruzi IgG antibodies can establish prior exposure to the infection.
Toxoplasma IgM-ELISA
6029
0.5-1.0 ml serum
This Toxoplasma IgM ELISA is to detect Toxoplasma gondii IgM-specific antibody for clinical identification of toxoplasmosis.
Toxoplasma IgG-ELISA
6028
0.5-1.0 ml serum
This Toxoplasma IgG ELISA is to detect Toxoplasma gondii IgG-specific antibody for clinical identification of toxoplasmosis.
SV40 (Simian Papovavirus-macaques) - DIA
130
0.5-1.0 ml serum
SV40 (vacuolating virus, papovavirus) is common to rhesus macaques where it has been associated with a progressive multifocal leuco-encephalopathy. SV40 has also been noted for producing tumors in rodents and transforming cells in culture. It has caused great concern as a contaminant in human vaccines prepared in monkey kidney cultures. There is some evidence that SV40 is associated with human cancer.
SV5 (Simian Parainfluenza Virus) - DIA
129
0.5-1.0 ml serum
SV5 is antigenically related to parainfluenza type 2. It has commonly been associated with rhesus macaques where it has caused problems by infecting primary monkey kidney cell cultures from infected animals. There is a possibility this is a human parainfluenza strain that has been transmitted to monkeys.
Simian T- lymphotropic virus type 2 (STLV-2) (Simian T-cell Leukemia Virus 2) -WB
W2118
0.5-1.0 ml serum
The STLV-2 western blot is a serology test method to detect anti-STLV-2 IgG antibody.
Simian T- lymphotropic virus type 2 (STLV-2) (Simian T-cell Leukemia Virus type 2)-ELISA
L2118
0.5-1.0 ml serum
STLV-2 is closely related to HTLV-2. STLV-2 has never been isolated from a South American spider monkey (Ateles geoffroyi) and pygmy chimpanzees (Pan paniscus). No clinical disease has been described to be associated with STLV-2 infection yet.
Simian T- lymphotropic virus type 1 (STLV-1) (Simian T-cell Leukemia Virus type 1)-DIA
118
0.5-1.0 ml serum
STLV-1 has been associated with lymphocytic neoplasia in gorillas, African green monkeys, baboons and several species of macaques. STLV-1 is antigenically closely related to the human virus HTLV-1. Although some macaque colonies have a rather high incidence of STLV-1 antibody, the occurrence of leukemias in these colonies is rare or non-existent.
Simian T- lymphotropic virus type 1 (STLV-1) (Simian T-cell Leukemia Virus 1) - WB
W118
0.5-1.0 ml serum
The STLV-1 western blot is a serology test method to detect anti-STLV-1 IgG antibody.
Simian T- lymphotropic virus type 1 (STLV-1) (Simian T-cell Leukemia Virus 1) - ELISA
L118
0.5-1.0 ml serum
STLV-1 has been associated with lymphocytic neoplasia in gorillas, African green monkeys, baboons and several species of macaques. STLV-1 is antigenically closely related to the human virus HTLV-1. Although some macaque colonies have a rather high incidence of STLV-1 antibody, the occurrence of leukemias in these colonies is rare or non-existent.
Squirrel monkey cytomegalovirus (SquiCMV) - DIA
109
0.5-1.0 ml serum
The squirrel monkey CMV was isolated from the salivary gland. Most adult squirrel monkeys and other New World monkeys have antibody to this squirrel monkey CMV. There has been no reported clinical disease due to this virus.
Simian Varicella Virus (SVV) - DIA
111
0.5-1.0 ml serum
Strains of simian varicella virus (SVV) have been involved in outbreaks of a varicella-like disease in African green, Patas and macaque monkeys. This virus is antigenically related to the human varicella virus.
Simian Varicella Virus (SVV) - ELISA
L111
0.5-1.0 ml serum
Strains of simian varicella virus (SVV) have been involved in outbreaks of a varicella-like disease in African green monkey, Patas and macaque monkeys. This virus is antigenically related to the human varicella virus.
Simian retrovirus type D (SRV) Group Specific Antibody-DIA
1110
0.5-1.0 ml serum
These type D retroviruses are noted for causing immunosuppression in infected macaques, leading to the development of opportunistic infections by other viruses, such as CMV and adenoviruses, as well as bacteria. These secondary infections are frequently fatal. There are currently 5 recognized types of macaque type D retroviruses (SRV1, 2, 3, 4, 5). As a group they all share a common group specific antigen. It should be emphasized that the detection of antibody does not preclude the presence of infectious virus in the antibody positive animal. In addition, antibody negative animals can be positive for infectious virus. Therefore, in order to develop an SRV negative colony, it is necessary to periodically screen for antibody and virus (by PCR or virus isolation) with removal of positive animals from the group. This may require one to two years to accomplish. See Lab. Animal Sci. .41: 123-127, 1991.
SRV type D Western Blot
W1110
0.5-1.0 ml serum
The SRV western blot is a serology test method to detect anti-SRV IgG antibody.
Simian Retrovirus type D (SRV) Group Specific Antibody-ELISA
L1110
0.5-1.0 ml serum
These type D retroviruses are noted for causing immunosuppression in infected macaques, leading to the development of opportunistic infections by other viruses, such as CMV and adenoviruses, as well as bacteria. These secondary infections are frequently fatal. There are currently 5 recognized types of macaque type D retroviruses (SRV1, 2, 3, 4, 5). As a group they all share a common group specific antigen. It should be emphasized that the detection of antibody does not preclude the presence of infectious virus in the antibody positive animal. In addition, antibody negative animals can be positive for infectious virus. Therefore, in order to develop an SRV negative colony, it is necessary to periodically screen for antibody and virus (by PCR or virus isolation) with removal of positive animals from the group. This may require one to two years to accomplish. See Lab. Animal Sci. .41: 123-127, 1991.
Simian Immunodeficiency Virus (SIV)-DIA
121
0.5-1.0 ml serum
SIV strains are found in a number of African primate species where they do not appear to cause any clinical disease. Macaque species infected with this virus suffer a fatal immunosuppressive disease. A number of SIV strains have been isolated from different primate species. Although they are distinguishable by molecular techniques, they are all closely related antigenically to each other and to the human viruses HIV-1 and 2. SIV has become a model for development of HIV vaccines. SIV infections of humans have been reported. It is not known if these infections will develop into clinical immunosuppression.
SIV - WB
W121
0.5-1.0 ml serum
The SIV western blot is a serology test method to detect anti-SIV IgG antibody.
Simian Immunodeficiency Virus (SIV) - ELISA
L121
0.5-1.0 ml serum
SIV strains are found in a number of African primate species where they do not appear to cause any clinical disease. Macaque species infected with this virus suffer a fatal immunosuppressive disease. A number of SIV strains have been isolated from different primate species. Although they are distinguishable by molecular techniques, they are all closely related antigenically to each other and to the human viruses HIV-1 and 2. SIV has become a model for development of HIV vaccines. SIV infections of humans have been reported. It is not known if these infections will develop into clinical immunosuppression.
Simian Hemorrhagic Fever Virus (SHFV) - DIA
134
0.5-1.0 ml serum
Simian hemorrhagic fever (SHF) causes a fatal hemorrhagic disease in macaques. The baboon and patas monkey are believed to be the natural host for this virus.
Simian Retrovirus isolation
301
5.0ml Heparinized blood or lymphoid tissue pieces
SRV and SIV are isolated from peripheral blood lymphocytes or lymphoid tissue (spleen, lymph nodes, bone marrow). The specimens should be kept cool on an ice pack (-20° C) during transport to the laboratory. It is important that the species of monkey be listed, as the blood from different monkeys requires different methods of processing. Positive cultures are usually seen within 7-10 days, however, the appearance of late cytopathology requires a 30 day incubation period before declaring a specimen negative.
Simian agent 8 (SA8) (African green monkey herpesvirus) - DIA
103
0.5-1.0 ml serum
SA8 is found in African green monkeys. It is capable of causing oral and genital lesions, as well as fatal neonatal infections. SA8 cross-reacts with herpesviruses found in other African nonhuman primates, as well as B virus and Herpes simplex 1 and 2. SA8 is not known to cause human infections.
African green monkey cytomegalovirus, SA6 (AgmCMV)-WB
W107
0.5-1.0 ml serum
The SA6 western blot is a serology test method to detect anti-SA6 IgG antibody.
African green monkey cytomegalovirus, SA6 (AgmCMV)-DIA
107
0.5-1.0 ml serum
This cytomegalovirus is a common contaminant of African green monkey kidney cell cultures, the source of the original isolation of this virus. However, virus has been isolated from the salivary gland. Most adult African green monkeys have antibody to SA6. No clinical disease has been attributed to this virus. Monkeys are often screened for SA6 antibody to select negative animals for kidney cell culture preparation.
Rotavirus (SA11) - DIA
139
0.5-1.0 ml serum
Rotaviruses are associated with gastrointestinal disease. SA11 antibody is common in simians. This assay detects antibody to specific and common antigens that are associated with all primate rotavirus strains. Infection of newborns causes diarrhea. Older animals do not show clinical signs of gastrointestinal disease.
Respiratory Syncytial Virus (RSV) - DIA
128
0.5-1.0 ml serum
Although it is not usually the case, RSV can cause life-threatening infections in chimpanzees and other apes. A number of monkey species are susceptible to RSV, however, clinical disease is generally mild.
Rabies Virus -DIA
137
0.5-1.0 ml serum
Rabies rarely occurs in captive nonhuman primates. This test is generally used to determine the antibody status of vaccinated animals.
Parainfluenza type 3 (Paraflu 3) - DIA
127
0.5-1.0 ml serum
Parainfluenza virus infections are quite common in nonhuman primates as evidenced by the prevalence of antibody. In general, these viruses produce mild or subclinical respiratory infections. However, neonates may be at increased risk for clinically severe infection.
Parainfluenza type 2 (Paraflu 2) - DIA
126
0.5-1.0 ml serum
Parainfluenza virus infections are quite common in nonhuman primates as evidenced by the prevalence of antibody. In general, these viruses produce mild or subclinical respiratory infections. However, neonates may be at increased risk for clinically severe infection.
Parainfluenza type 1 (Paraflu 1) - DIA
125
0.5-1.0 ml serum
Parainfluenza virus infections are quite common in nonhuman primates as evidenced by the prevalence of antibody. In general, these viruses produce mild or subclinical respiratory infections. However, neonates may be at increased risk for clinically severe infection.
Monkeypox (Copenhagen Strain) - DIA
133
0.5-1.0 ml serum
A number of monkeypox outbreaks occurred in macaques in the 1960’s, but no reports have appeared since then. The monkeypox virus infects apes, baboons, owl monkeys, squirrel monkeys and marmosets with varying degrees of pathogenicity and fatalities. The virus was also implicated in human infections in Africa.
Measles - ELISA
L112
0.5-1.0 ml serum
Measles virus is capable of infecting a number of New World and Old World monkeys and apes. Measles can produce a fatal giant cell pneumonia in adult monkeys, and has caused abortions in a high percentage of pregnant females. Tamarins are especially susceptible to measles infection, causing fatal infections. For this reason vaccination is employed routinely with some monkeys. The presence of IgG antibody will prevent infection.
Measles - DIA
112
0.5-1.0 ml serum
Measles virus is capable of infecting a number of New World and Old World monkeys and apes. Measles can produce a fatal giant cell pneumonia in adult monkeys, and has caused abortions in a high percentage of pregnant females. Tamarins are especially susceptible to measles infection, causing fatal infections. For this reason, vaccination is employed routinely with some monkeys. The presence of IgG antibody will prevent infection.
Lymphocytic Choriomeningitis Virus (LCMV) - DIA
132
0.5-1.0 ml serum
LCMV, a rodent virus, is associated with a rapidly progressive hepatitis and has been implicated in a number of fatal epizootics in captive marmosets and tamarins.
Leptospirosis - ELISA
151
0.5-1.0 ml serum
Leptospirosis is caused by infection with the genus Leptospira. Naturally acquired leptospirosis has been reported in a tamarin (Saguinus labiatus), a chimpanzee, squirrel monkeys, baboons (Papio spp.), and Barbary macaques/Barbary apes (Macaca sylvana). Clinical signs include lethargy, icterus, dyspnea, epistaxis, hemorrhage from the mouth, abortion, and death. Rising antibody titers to leptospiral antigen are detected by indirect hemagglutination test for leptospirosis diagnosis.
Foamyvirus, Group Specific - DIA
136
0.5-1.0 ml serum
There are more than 10 different serotypes of foamyviruses found in nonhuman primates, each associated with a particular simian species. A common group specific antigen is shared by those foamyvirus strains that have been tested. Presence of group specific foamyvirus antibody is indicative of foamyvirus infection. These infections usually occur early in life, resulting in a latent infection in peripheral lymphocytes which persists for life and may result in recurrent expression of infectious virus in the buccal cavity. Foamyviruses have not been associated with disease in primates, with the possible exception of a mild immunosuppression. They are most commonly encountered in cultures of tissues from infected animals, where they cause destruction of the cell culture. There is some evidence of human infections with foamyviruses with no evidence of clinical disease.
Influenza B (Flu B) - DIA
124
0.5-1.0 ml serum
Natural infection of nonhuman primates by influenza virus has been reported as have experimental infections. In general these infections are mild with little or no clinical symptoms occurring.
Influenza A (Flu A) - DIA
123
0.5-1.0 ml serum
Natural infection of nonhuman primates by influenza virus has been reported as have experimental infections. In general these infections are mild with little or no clinical symptoms occurring.
Human Varicella-Zoster Virus (VZV) (Chickenpox virus) - DIA
140
0.5-1.0 ml serum
Human Varicella herpesvirus has been shown to infect great apes, producing typical “chickenpox”-like skin lesions.
Herpesvirus tamarinus (Saimiriine herpesvirus 1, SaHV-1; Herpesvirus saimiri 1, HVS-1) - DIA
104
0.5-1.0 ml serum
H. tamarinus is indigenous to the squirrel monkey where it causes oral lesions and latent infections. It causes fatal infections in marmosets, tamarins and owl monkeys, but not Old World monkeys or humans.
Herpesvirus saimiri (Saimiriine herpesvirus 2, SaHV-2; Herpesvirus saimiri 2, HVS-2) - DIA
105
0.5-1.0 ml serum
H. saimiri is a T-lymphotropic rhadinovirus found in squirrel monkey T-cells. Although it is not known to produce a clinical disease in squirrel monkeys, it does cause a fatal lymphoproliferative disease in marmosets, tamarins and owl monkeys and is able to transform T-lymphocytes to perpetual growth. It has not been shown to infect humans.
Herpesvirus papio 2 (HVP-2) (Papiine herpesvirus 2, PaHV-2) - DIA
114
0.5-1.0 ml serum
HVP-2 is detected in most adult captive baboons, but no data on the presence of HVP-2 in wild baboons yet. HVP-2 can cause oral and genital lesions in baboons similar to those casued by HSV in humans. HVP-2 has ever been isolated from a fatal case in a colobus monkey, indicating this virus may infect primate species other than baboons.
Herpes simplex virus 2 (HSV-2) (Herpesvirus hominis type 2) - DIA
102
0.5-1.0 ml serum
As with HSV-1, HSV-2 can infect a number of nonhuman primates with varying degrees of clinical illness. This virus also cross-reacts with Herpes B virus.
Herpes simplex virus type 1 ( HSV-1) (Herpesvirus hominis type 1) - DIA
101
0.5-1.0 ml serum
HSV-1 is able to infect many nonhuman primates (such as owl monkeys , gibbons, gorillas, tree shrews and chimpanzees et.al.) with varying degrees of clinical disease. The HSV-1 antibody cross-reacts with B virus.
B virus - WB
W100
0.5-1.0 ml serum
The B virus western blot is a serology test method to detect anti-B virus IgG antibody.
Hepatitis C Antibody (Anti-HCV) - CMIA
3202
0.5-1.0 ml serum
Although there are reports of HCV antibody positive nonhuman primates, the number of species susceptible to this virus has not been studied in detail. Hepatitis C has been demonstrated in chimpanzees.
Hepatitis B Core IgM Antibody (IgM Anti-HBc) - CMIA
7024
0.5-1.0 ml serum
Hepatitis B core antibody is found in acute or convalescent sera following recovery and during chronic-carrier infections.
Hepatitis B Core IgG and IgM Antibody (Anti-HBc) - CMIA
2202
0.5-1.0 ml serum
Hepatitis B core antibody is found in acute or convalescent sera following recovery and during chronic-carrier infections.
Hepatitis B Surface Antigen (HBsAg) - CMIA
1202
0.5-1.0 ml serum
In an acute infection, hepatitis B surface antigen is present in serum for several months before antibody appears and the infection resolves. If a chronic-carrier state develops, surface antigen may persist for a lifetime. Chimpanzees are known to be susceptible to hepatitis B infection and in some instances chronic hepatitis has been demonstrated.
Hepatitis B Surface Antigen Antibody (anti-HBs) - CMIA
202
0.5-1.0 ml serum
Hepatitis B surface antigen antibody arises in the recovery phase of a hepatitis B infection, persists over a long period of time and is useful in a screen for immunity, as well as previous exposure. Hepatitis B can infect apes but is not known to occur in New or Old World monkeys.
Hepatitis A (IgM) Antibody - CMIA
201
0.5-1.0 ml serum
HAV IgM antibody appears during the early acute infectious stage of HAV infection and persists through the acute stage (3-6 months) in humans.
Hepatitis A Total Antibody - EIA
200
0.5-1.0 ml serum
This test detects any HAV antibody (IgG, IgM, IgA) and only indicates a previous infection. Chimpanzees, macaques, African greens, baboons, owl monkeys, cebus monkeys and marmosets have all been shown to be susceptible to HAV infection experimentally or by the presence of antibody. HAV isolates from macaques and owl monkeys are closely related to human HAV, but may differ in host pathogenicity.
Filovirus-EBOLA (Reston Strain) - DIA
1135
0.5-1.0 ml serum
The Reston strain of simian filovirus is antigenically related to human EBOLA virus. It causes a fatal hemorrhagic disease in monkeys. Although there is serological evidence that this virus infects humans, it does not appear to cause a clinical disease. This virus originated in the Philippine Islands in contrast to the EBOLA virus, which is found in Africa.
Encephalomyocarditis Virus (EMCV) - DIA
131
0.5-1.0 ml serum
EMCV has infected a number of primate species, including chimpanzees, baboons and squirrel monkeys where a number of deaths occurred. Rodent transmission is believed to be the source of this virus.
Epstein-Barr Virus (EBV) - DIA
110
0.5-1.0 ml serum
EBV, a B-cell lymphotropic gamma herpesvirus, causes infectious mononucleosis in humans and has been shown to infect several species of primates. Nonhuman primates (Chimpanzees, gibbons, orangutans, baboons, and macaques) have been shown to harbor similar B-cell viruses that are antigenically related to EBV. Experimental infection of macaques with their indigenous virus produces an infectious mononucleosis-like disease. Other primate strains have not been studied. EBV antibody positive animals most likely are reflecting infection with their indigenous gamma herpesviruses.
Rhesus monkey cytomegalovirus (RhCMV) (Macaca spp. Cytomegalovirus) - DIA
106
0.5-1.0 ml serum
This cytomegalovirus was isolated from the urine of a rhesus monkey. It is used to test for CMV antibody in Asian monkeys. Most adult Asian monkeys have antibody to this virus. There is generally no apparent clinical disease associated with CMV in these monkeys unless they are immunosuppressed by infection with another virus (e.g. SRV) or treatment with drugs.Immunosuppressed animals may develop noma or pneumonia. RhCMV can be isolated from lymphocytes as well as other tissues in these animals.
Chimpanzee cytomegalovirus (ChCMV or CCMV) - DIA
108
0.5-1.0 ml serum
This cytomegalovirus has been isolated from the throat and urine of normal adult chimpanzees. Most adult chimpanzees have antibody to this virus. No clinical disease has been attributed to chimpanzee CMV.
Adenovirus, Group Specific Antibody - DIA
120
0.5-1.0 ml serum
All of the simian adenoviruses share a common antigen with one another and human adenoviruses. Adenovirus infections are common in nonhuman primates, having been associated with upper respiratory disease (coryza, rhinitis, conjunctivitis) and diarrhea. This test is designed to screen for the presence of adenovirus antibody without identifying the specific agent involved.
B virus (Cercopithecine herpesvirus 1, CeHV-1; Herpesvirus simiae )-DIA
100
0.5-1.0 ml serum
B virus is common to Macca spp. where it can cause oral, ocular or genital lesions similar to herpes simplex virus 1 in humans. Once a macaque is infected it is thought to retain the virus in a latent form throughout life, with possible recurrent clinical symptoms. B virus is not naturally found in other monkey species or apes, although this may occur through exposure to infected macaques. Infection of human contacts can be fatal, however, treatment with antiviral drugs has been successful when used early in the infection.
B virus (Cercopithecine herpesvirus 1, CeHV-1; Herpesvirus simiae )-ELISA
Test Code
L100
0.5-1.0 ml serum
B virus is common to Macca spp. where it can cause oral, ocular or genital lesions similar to herpes simplex virus 1 in humans. Once a macaque is infected it is thought to retain the virus in a latent form throughout life, with possible recurrent clinical symptoms. B virus is not naturally found in other monkey species or apes, although this may occur through exposure to infected macaques. Infection of human contacts can be fatal, however, treatment with antiviral drugs has been successful when used early in the infection.
Burkholderia pseudomallei-ELISA
L115
0.5-1.0 ml serum
Burkholderia pseudomallei is a Gram-negative bacillus. It is a Biosafety Level 3 select agent causing Melioidosis, which can be fatal if untreated. It is found in soils throughout southeast Asia and northern Australia, with sporadic infections in many parts of the world.